Benet, Leslie Z : rechercher sur Z-Library

Giacomini, Kathleen M., Huang, Shiew-Mei, Tweedie, Donald J., Benet, Leslie Z., Brouwer, Kim L.R., Chu, Xiaoyan, Dahlin, Amber, Evers, Raymond, Fischer, Volker, Hillgren, Kathleen M.

Année:

1973

Langue:

english

Fichier:

PDF, 653 KB

english, 1973

Membrane transporters in drug development

Journal:

Nature Reviews Drug Discovery

Année:

2010

Langue:

english

Fichier:

PDF, 646 KB

english, 2010

Two-compartment model for a drug and its metabolite: Application to acetylsalicylic acid pharmacokinetics

Malcolm Rowland, Leslie Z. Benet, Sidney Riegelman

Journal:

Année:

1970

Langue:

english

Fichier:

PDF, 360 KB

english, 1970

Effect of route of administration and distribution on drug action

Leslie Z. Benet

Journal:

Selma Sahin, Leslie Z. Benet

Année:

1978

Langue:

english

Fichier:

PDF, 1.64 MB

english, 1978

The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms

Journal:

Sarah Shugarts, Leslie Z. Benet

Année:

2008

Langue:

english

Fichier:

PDF, 273 KB

english, 2008

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

Journal:

Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas, Lawrence X. Yu

Année:

2009

Langue:

english

Fichier:

PDF, 314 KB

english, 2009

The BCS, BDDCS, and Regulatory Guidances

Journal:

Benet, Leslie Z., Levy, Gerhard, Ferraiolo, Bobbe L.

Année:

2011

Langue:

english

Fichier:

PDF, 124 KB

english, 2011

Pharmacokinetics || Estimation of an Effective Half-Life

Année:

1984

Langue:

english

Fichier:

PDF, 1.24 MB

english, 1984

Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Subjects and Patients with Noninsulin-Dependent Diabetes Mellitus

Sambol, Nancy C., Chiang, Janie, O'Conner, Michael, Liu, Chui Y., Lin, Emil T., Goodman, Anita M., Benet, Leslie Z., Karam, John H.

Journal:

Journal of Clinical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 973 KB

english, 1996

Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations

Parasrampuria, Dolly A., Benet, Leslie Z., Sharma, Amarnath

Journal:

Benet, Leslie Z., Sodhi, Jasleen K.

Année:

2018

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2018

Investigating the Theoretical Basis for In VitroâIn Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways

Journal:

Leslie Z. Benet, Joseph S. Turi

Année:

2020

Fichier:

PDF, 800 KB

2020

Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis

Journal:

Robert A. Ronfeld, Leslie Z. Benet

Année:

1971

Langue:

english

Fichier:

PDF, 203 KB

english, 1971

Interpretation of plasma concentration-time curves after oral dosing

Journal:

Gomez, Denise Y., Wacher, Vincent J., Tomlanovich, Stephen J., Hebert, Mary F., Benet, Leslie Z.

Année:

1977

Langue:

english

Fichier:

PDF, 386 KB

english, 1977

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

Journal:

Clinical Pharmacology & Therapeutics

Année:

1995

Langue:

english

Fichier:

PDF, 527 KB

english, 1995

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

Wu, Chi-Yuan, Benet, Leslie Z., Hebert, Mary F., Gupta, Suneel K., Rowland, Malcolm, Gomez, Denise Y., Wacher, Vincent J.

Journal:

Clinical Pharmacology & Therapeutics

Année:

1995

Langue:

english

Fichier:

PDF, 604 KB

english, 1995

Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation

Anita Grover, Leslie Z. Benet

Journal:

Chi-Yuan Wu, Leslie Z. Benet

Année:

2011

Langue:

english

Fichier:

PDF, 307 KB

english, 2011

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 388 KB

english, 2005

Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System

Leslie Z. Benet

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 463 KB

english, 2010

BDDCS Class Prediction for New Molecular Entities

Broccatelli, Fabio, Cruciani, Gabriele, Benet, Leslie Z., Oprea, Tudor I.

Journal:

Molecular Pharmaceutics

Année:

2012

Langue:

english

Fichier:

PDF, 451 KB

english, 2012

Effects of Drug Transporters on Volume of Distribution

Anita Grover, Leslie Z. Benet

Journal:

Margareta Hammarlund-Udenaes, Leslie Z. Benet

Année:

2009

Langue:

english

Fichier:

PDF, 197 KB

english, 2009

Furosemide pharmacokinetics and pharmacodynamics in health and disease—An update

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 2.80 MB

english, 1989

Pharmacokinetics/pharmacodynamics of furosemide in man: A review

Leslie Z. Benet

Journal:

Ching S. Lee, Thomas C. Marbury, Leslie Z. Benet

Année:

1979

Langue:

english

Fichier:

PDF, 1.62 MB

english, 1979

Clearance calculations in hemodialysis: Application to blood, plasma, and dialysate measurements for ethambutol

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 726 KB

english, 1980

Pharmacokinetics of cefamandole using a HPLC assay

Nik S. Aziz, John G. Gambertoglio, Emil T. Lin, Henry Grausz, Leslie Z. Benet

Journal:

Linda E. Gustavson, Leslie Z. Benet

Année:

1978

Langue:

english

Fichier:

PDF, 643 KB

english, 1978

Menopause: Pharmacodynamics and pharmacokinetics

Journal:

Experimental Gerontology

Année:

1994

Langue:

english

Fichier:

PDF, 442 KB

english, 1994

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

Joseph M. Custodio, Chi-Yuan Wu, Leslie Z. Benet

Journal:

Advanced Drug Delivery Reviews

Année:

2008

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2008

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

Benet, Leslie Z.

Journal:

International Journal of Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 234 KB

english, 2013

Report of the workshop on: in vitro and in vivo testing and correlation for oral controlled/modified release dosage forms

Skelly, Jerome P., Amidon, Gordon L., Barr, William H., Benet, Leslie Z., Carter, James E., Robinson, Joseph R., Shah, Vinod P., Yacobi, Avraham, Aiache, Jean-Marc, Albert, Kenneth S., Amidon, Gordon

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 1.11 MB

english, 1990

Gastric Reacidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

Yago, Marc R., Frymoyer, Adam R., Smelick, Gillian S., Frassetto, Lynda A., Budha, Nageshwar R., Dresser, Mark J., Ware, Joseph A., Benet, Leslie Z.

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 239 KB

english, 2013

The True Composition of Kidney Stones Passed During Triamterene Therapy

Sörgel, Fritz, Ettinger, Bruce, Benet, Leslie Z.

Journal:

The Journal of Urology

Année:

1985

Langue:

english

Fichier:

PDF, 122 KB

english, 1985

Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Phung, Nhi, Kuncze, Karen, Okochi, Hideaki, Louie, Alexander, Benet, Leslie Z., Ofokotun, Igho, Haas, David W., Currier, Judith S., Chawana, Tariro D., Sheth, Anandi N., Bacchetti, Peter, Gandhi, Moni

Journal:

Rapid Communications in Mass Spectrometry

Année:

2018

Langue:

english

Fichier:

PDF, 918 KB

english, 2018

Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States

Koss, Catherine A, Hosek, Sybil G, Bacchetti, Peter, Anderson, Peter L, Liu, Albert Y, Horng, Howard, Benet, Leslie Z, Kuncze, Karen, Louie, Alexander, Saberi, Parya, Wilson, Craig M, Gandhi, Monica

Journal:

Clinical Infectious Diseases

Année:

2018

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2018

Characterization of fasiglifam-related liver toxicity in dogs

Kogame, Akifumi, Moriya, Yuu, Mori, Ikuo, Pan, Liping, Morohashi, Akio, Ebihara, Takuya, Fukui, Hideo, Tagawa, Yoshihiko, Benet, Leslie Z.

Journal:

Drug Metabolism and Disposition

Année:

2019

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2019

How Transporters Have Changed Basic Pharmacokinetic Understanding

Benet, Leslie Z., Bowman, Christine M., Sodhi, Jasleen K.

Journal:

Surofchy, Dalga D., Frassetto, Lynda A., Benet, Leslie Z.

Année:

2019

Langue:

english

Fichier:

PDF, 853 KB

english, 2019

Food, Acid Supplementation and Drug Absorption – a Complicated Gastric Mix: a Randomized Control Trial

Journal:

Sodhi, Jasleen K., Benet, Leslie Z.

Année:

2019

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2019

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

ChemMedChem

Année:

2020

Fichier:

PDF, 1.27 MB

2020

The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions

Journal:

Takashi Mizuma, Leslie Z. Benet, Emil T. Lin

Année:

2020

Fichier:

PDF, 491 KB

2020

Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite

Journal:

Drug Development Research

Année:

1999

Langue:

english

Fichier:

PDF, 157 KB

english, 1999

Development of 3-nitratomethyl-proxyl (NMP): A novel, bifunctional superoxide dismutase-mimic-nitric oxide-donor

Abdullah Haj-Yehia, Taher Nassar, Chaim Lotan, Thomas Münzel, Leslie Benet, Erik E. Änggård

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 140 KB

english, 2000

Absorption kinetics of cyclosporine in healthy volunteers

Suneel K. Gupta, Leslie Z. Benet

Journal:

David T.-W. Lau, Mark Gumbleton, Christoph Labisch, Leslie Z. Benet

Année:

1989

Langue:

english

Fichier:

PDF, 265 KB

english, 1989

Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat

Journal:

Margareta Hammarlund-udenaes, Leslie Z. Benet

Année:

1991

Langue:

english

Fichier:

PDF, 393 KB

english, 1991

Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 571 KB

english, 1991

Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration

Chao Han, Paul Jung, Steven W. Sanders, Emil T. Lin, Leslie Z. Benet

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 249 KB

english, 1994

Time course of cyclosporine and its metabolites in blood, liver and spleen of naive lewis rats: Comparison with preliminary data obtained in transplanted animals

Vincent J. Wacher, Tao Liu, John P. Roberts, Nancy L. Ascher, Leslie Z. Benet

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 521 KB

english, 1995

Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing

Dale K. Yu, Dennis H. Giesing, Roger L. Williams, Leslie Z. Benet, Emil T. Lin

Journal:

Catheterization and Cardiovascular Interventions

Année:

1988

Langue:

english

Fichier:

PDF, 401 KB

english, 1988

Novel percutaneous adventitial drug delivery system for regional vascular treatment

Fumiaki Ikeno, Jennifer Lyons, Hideaki Kaneda, Muhammad Baluom, Leslie Z. Benet, Mehrdad Rezaee

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 597 KB

english, 2004

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers

Sascha Mayer, Ernst Mutschler, Dr. Hildegard Spahn-Langguth, Leslie Z. Benet

Journal:

Chirality

Année:

1993

Langue:

english

Fichier:

PDF, 585 KB

english, 1993

Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus

K. Olaf Boernsen, Wolfgang Egge-Jacobsen, Bruno Inverardi, Tobin Strom, Frank Streit, Hans-Martin Schiebel, Leslie Z. Benet, Uwe Christians

Journal:

Journal of Mass Spectrometry

Année:

2007

Langue:

english

Fichier:

PDF, 198 KB

english, 2007

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells

Shawn D. Flanagan, Lpori H. Takahashi, Xiaoli Liu, Leslie Z. Benet

Journal:

Wendy S. Putnam, Srinivasan Ramanathan, Lin Pan, Lori H. Takahashi, Leslie Z. Benet

Année:

2002

Langue:

english

Fichier:

PDF, 148 KB

english, 2002

Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells

Journal: